The Past and Future of Clinical Trials - Part I

Posted by Fuad Rahman on May 20, 2019 8:02:41 AM

Today is a very important day on our calendar – it’s International Clinical Trials Day, May the 20th. Dr. James Lind is recognized as the first physician to have conducted a controlled clinical trial in the modern era. Lind was a Scottish naval surgeon and worked on British Royal Navy ships in the 16th century. He noticed the high mortality of scurvy among the sailors and planned a comparative trial of the most promising cure for this ailment. The date he conducted this trial was May 20th, 1747.

Clinical trials have come a long way since Lind’s search for a cure for scurvy. But we still have a long way to go. Let’s start with a sobering statistic: Of all the drugs started in clinical trials on humans, only 10 percent secure approval. Not only that, roughly only 1 in every 5,000 compounds that drug companies discover and put through preclinical testing ultimately becomes an approved drug. These statistics are about drugs, but that is not the only scope for clinical trials. Clinical trials are designed to answer specific questions about new treatments, such as novel vaccines, drugs, but they also focus on new dietary choices, dietary supplements, and medical devices. So the impact of failed clinical trials is enormous—not only because it comes at a huge financial loss, but even more because it implies a direct loss of human lives—by not allowing lifesaving drugs, procedures, and medical devices to be available in time.

Why are clinical trials so prone to failure? There are many reasons.

A significant number of clinical trials fail every year because of inadequate financial support, poor protocol designs, an inability to recruit the right patients, and a lack of good software tools to conduct the trial, among other reasons. By consequence, lifesaving drugs, innovative devices, and great research fail to reach the patients who need help desperately.

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Trials.ai joins JLABS!

Posted by Mike Nicoletti on Mar 15, 2019 3:00:00 PM

We are excited to announce that Trials.ai is now a resident company of Johnson & Johnson Innovation, JLABS San Diego, a premier life science incubator program. JLABS is a global network of open innovation ecosystems, enabling and empowering innovators to create and accelerate the delivery of life-enhancing health and wellness solutions to patients around the world.  As a leader in innovation, JLABS helps entrepreneurs in pharmaceutical, medical device, consumer, and health tech bring healthcare solutions to patients and consumers.

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Trials.ai Presents at Nex Cubed Winter Showcase

Posted by Mike Nicoletti on Feb 2, 2018 2:12:00 PM

A packed out crowd gathered with excitement at the Sway / Nex Cubed headquarters in the SF financial district for the Nex Cubed winter showcase. Momentarily, Kelsey Morgan, co-founder of Nex Cubed would unveil the latest cohort of incubating companies.

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